Palladium-Catalyzed Oxidative Cross-Coupling of <i>N-</i>Tosylhydrazones with Indoles: Synthesis of <i>N-</i>Vinylindoles

Abstract

A general and efficient palladium-catalyzed oxidative cross-coupling reaction of N-tosylhydrazones with indoles providing N-vinylindoles has been developed. The reaction proceeds smoothly with various indoles and N-tosylhydrazones in a stereocontrolled manner, and a wide variety of N-vinylindoles were obtained up to 99% yields for 26 examples.