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Determination of oxymetazoline hydrochloride and decomposition products by high-performance liquid chromatography.
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2001
Year
EngineeringDecomposition ProductsOrganic ChemistryChemistryAntazoline MethanesulfonateChemical EngineeringOxymetazoline HydrochlorideSeparation ScienceGas ChromatographySelective SeparationAnalytical ChemistryLiquid ChromatographyAdvanced SeparationChromatographyChromatographic AnalysisPharmacologyHigh-performance Liquid ChromatographyEnvironmental EngineeringInternal StandardMedicineDrug Analysis
An HPLC method for the separation of the oxymetazoline hydrochloride and the products of its decomposition was developed and validated. The determination was performed with a LiChrospher RP-18 column, mobile phase of methanol-H2O-triethylamine-sodium acetate (1 mol l(-1))-acetic acid (1.06 kg l(-1)) (130:60:6:2:1). UV detector set at 280 nm and antazoline methanesulfonate as an internal standard.