Adaptive responses to cefotaxime treatment in ESBL-producing<i>Escherichia coli</i>and the possible use of significantly regulated pathways as novel secondary targets

Abstract

The results show that ESBL-producing E. coli adapt to treatment with cefotaxime by changing their gene expression patterns and furthermore that targeting regulated adaptive pathways may be a suitable way to identify targets for drugs that will specifically inhibit the resistant bacteria.