Flurofamide: A Potent Inhibitor of Bacterial Urease with Potential Clinical Utility in the Treatment of Infection Induced Urinary Stones

Abstract

No AccessJournal of Urology1 Feb 1982Flurofamide: A Potent Inhibitor of Bacterial Urease with Potential Clinical Utility in the Treatment of Infection Induced Urinary Stones O.E. Millner, J.A. Andersen, M.E. Appler, C.E. Benjamin, J.G. Edwards, D.T. Humphrey, and E.M. Shearer O.E. MillnerO.E. Millner , J.A. AndersenJ.A. Andersen , M.E. ApplerM.E. Appler , C.E. BenjaminC.E. Benjamin , J.G. EdwardsJ.G. Edwards , D.T. HumphreyD.T. Humphrey , and E.M. ShearerE.M. Shearer View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53779-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A novel compound, N-[diaminophosphinyl]-4-fluorobenzamide (given the USAN name flurofamide), has been found to be a potent inhibitor of bacterial urease. The compound, coded EU-4534, is approximately 1000 times more potent than acetohydroxamic acid as an inhibitor of the urease in intact P. mirabilis cells. Flurofamide is excreted in the urine of rats and dogs following oral administration and is effective in retarding stone formation in the urinary tract of rats infected with P. mirabilis. Measurements of urinary recoveries of urease inhibitory activity following administration of flurofamide indicate that efficacy might be achieved in humans at doses under 1mg./kg. © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByLerner S, Gleeson M and Griffith D (2018) Infection StonesJournal of Urology, VOL. 141, NO. 3 Part 2, (753-758), Online publication date: 1-Mar-1989. Volume 127Issue 2February 1982Page: 346-350 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information O.E. Millner More articles by this author J.A. Andersen More articles by this author M.E. Appler More articles by this author C.E. Benjamin More articles by this author J.G. Edwards More articles by this author D.T. Humphrey More articles by this author E.M. Shearer More articles by this author Expand All Advertisement PDF DownloadLoading ...