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Cytotoxicity, antitumoral and antimycobacterial activity of tetrazole and oxadiazole derivatives.
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2005
Year
PharmacotherapyAntimicrobial ChemotherapyAntimycobacterial ActivityPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryStructure Activity RelationshipAntimicrobial TherapyPrincipal Component AnalysisBiochemistryTuberculosisAntibacterial AgentAntimicrobial CompoundPharmacologyAntiviral CompoundNatural SciencesMicrobiologyAntimicrobial AgentsMedicineDrug DiscoveryDrug Analysis
In this study, the antimycobacterial activity of mono and di-substituted tetrazole and oxadiazole derivatives and their precursors was assayed on Mycobacterium tuberculosis H37Rv, and cytotoxicity was evaluated on J774 macrophages and on tumoral cell lines. Structure Activity Relationship (SAR) analysis was performed using Principal Component Analysis (PCA) to determine the relationship between these compounds and their biological activities.