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Interaction of Low Doses of Ionizing Radiation and CarbonTetrachloride on Liver Superoxide Dismutase and GlutathionePeroxidase in Mice

DOI

14

Citations

0

References

1985

Year

Maurizio Manno, A. Bertazzon, Angelo Burlina, L Galzigna
Enzyme

Abstract

Male BALB/c mice were treated with intraperitoneal injections of carbon tetrachloride (CCl4) (0.2 g/kg body weight) and/or 50 R of whole-body gamma irradiation, three times per week, for 4 weeks. The effects of the treatments on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver extracts and homogenates, and on alkaline phosphatase (ALP) in serum were investigated. A significant decrease in the SOD and GSH-Px activities in liver extracts and an increase of serum ALP of hepatic origin were found in CCl4-treated animals. In contrast, only an increase in SOD activity was observed in liver homogenates after the combined treatment.