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Hormonal regulation of active chloride transport in the dogfish rectal gland
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1979
Year
Cellular PhysiologyGastrointestinal Peptide HormoneNeuroendocrine MechanismElectrolyte HomeostasisOsmoregulationAnimal PhysiologyMolecular PhysiologySodium HomeostasisCyclic AmpEndocrinologyPharmacologyHormonal RegulationVasoactive Intestinal PeptideBiologySignal TransductionDogfish Rectal GlandPhysiologyActive Chloride TransportMedicineComparative Physiology
Active transport of chloride is modulated by cyclic AMP in the rectal gland of Squalus acanthias. Vasoactive intestinal peptide (VIP) specifically activates the production of cyclic AMP by the gland and stimulates the secretion of chloride. Somatostatin inhibits VIP-induced secretion but has no effect alone. Both these peptides are present in the dogfish shark and may play an important role in electrolyte homeostasis.