MedicineOncologyOphthalmologyOcular DiseaseOcular PathologyOcular PharmacologyMedication Effects On VisionOcular PharmacodynamicsOcular TolerabilityAdverse Ocular EffectsOcular Health AssessmentOcular Toxicity EvaluationOuter Retinal ChangesRetinal Microvascular ChangesRetinal Pigment Epithelium ChangesTamoxifen Retinopathy
Tamoxifen is a specific estrogen antagonist used in the treatment of breast cancer. In a previous study, corneal and retinal changes were reported in four patients receiving high-dose tamoxifen therapy for greater than 1 year. Nineteen patients treated with tamoxifen for periods of 3 months to 4 years at normal dose levels have been studied and no ocular changes attributable to the drug were observed.