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Pharmacological profile of TCV-309--a potent PAF antagonist.
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1992
Year
ImmunologyVascular IrritationPharmacotherapyImmunotherapyPlatelet AggregationInflammationMolecular PharmacologyThrombosisVascular PermeabilityHematologyPlatelet AntagonistPharmacological AgentVascular BiologyPharmacologyBlood PlateletHemostasisPotent Paf AntagonistCoagulopathyMedicineDrug Discovery
TCV-309 potently and specifically inhibited the diverse biological actions of PAF such as platelet aggregation, hypotension, increased vascular permeability, bronchoconstriction and death. TCV-309 did not cause hemolysis or vascular irritation. TCV-309 showed beneficial effects on experimental endotoxic shock, anaphylactic shock and disseminated intravascular coagulation.