PubMed · 2015 · 40 citations · 11 references
MedicineOncologyPathologyMetastasisMolecular OncologyOncogenesHepatic PathologyHepatobiliary CancerHepatocellular CarcinomaLiver CancerLiver MetastasisMalignant NeoplasmsCancer Metastasis BiomarkersDisease PrognosisDistant Metastasis DetectionHepatic MalignancyHepatocellular Carcinoma MetastasisKi-67 ImmunostainingMetastasis RiskTissue Microarray Analysis
The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.
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Gene Expression Patterns in Human Liver Cancers
Xin Chen, Samuel So, Sheung Tat Fan et al. · Molecular Biology of the Cell · 2002 · 862 citations · Full text