The Histochemical Study of Zinc Content in Granulocytes in Normal Adults and in Hematologic Disorders

Abstract

Abstract Zinc in granulocytes was determined using a dithizone histochemical method. Investigations were performed in both bone marrow and in peripheral blood from ten healthy adults and in 62 patients with various hematologic disorders. In bone marrow, zinc appears in metamyelocytes. The amount increases with maturation. In the granulocytes of peripheral blood, zinc values are about 30 per cent higher than in bone marrow. Zinc is significantly decreased in granulocytes in chronic granulocytic leukemia, acute myeloblastic leukemia, multiple myeloma and Hodgkin’s and increased in chronic lymphocytic leukemia and osteomyelosclerosis.