[Microbiological laboratory studies with ciclopiroxolamine (author's transl)].

Abstract

A survey is given on the microbiological laboratory results obtained up to date with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen). The activity spectrum of the drug on fungi, bacteria and other organisms is described. Various properties by which Cic differs from commercial antimycotics are mentioned. They concern the great uniformity of MICs in pathogenic fungi, their consistency under various test conditions, the importance of the nutrient medium for the level of in vitro activity, and the steepness of dose-response curves. In addition, previously described properties of Cic are summarized, including findings on its mode of action in fungi, its effect in model mycoses, and its high efficacy in hornified skin types. The relevance of laboratory findings for therapy is discussed.