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Nondestructive analysis of mitral valve collagen fiber orientation.
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1992
Year
Tissue EngineeringEngineeringMechanotransductionBiomedical EngineeringTissue ImagingChordal Collagen UltrastructureBiomechanicsMv LeafletValve DiseaseMatrix BiologyBiophysicsCardiovascular ImagingMechanobiologyNondestructive AnalysisMitral ValveCell BiomechanicsFiber StructureBiomedical ImagingMedicineHuman TissueExtracellular Matrix
Collagen is the most abundant and highest modulus component in mitral valve (MV) tissue. MV leaflet and chordal collagen ultrastructure were analyzed by small angle light scattering (SALS) and polarized light microscopy (PLM) to provide collagen fiber architecture mapping. It was hypothesized that structural arrangement strongly influences MV tissue mechanical properties and thus physiologic function.