Over-the-counter codeine analgesic misuse and harm: characteristics of cases in Australia and New Zealand.

Abstract

This study has identified that controls on OTC codeine analgesics in both countries were not sufficient to limit non-medical use of these products. As a result, cases identified in these two countries escalated the number of self-administered tablets taken daily for misuse, resulting in codeine dependence and serious NSAID toxicity secondary to this dependence.