Immunocytochemical expression of Ki67 and laminin in Hurthle cell adenomas and carcinomas.

Abstract

These findings support the hypothesis that benign Hurthle cell lesions with a high cellular proliferation associated with an increased laminin expression could define a subset of lesions prone to malignant transformation. Conversely, since all cases with low expression of both laminin and Ki67 always correspond to adenomas, we suggest that the different expression of these two antibodies on FNAC can provide a further tool for the preoperative identification of lesions at low risk of malignancy, thus avoiding unnecessary surgery.