VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to<i>Plasmodium falciparum</i>Placental Malaria

Abstract

Broadly neutralizing antibodies of multigravidae are not depleted on VAR2CSA recombinant antigens, and hence development of VAR2CSA vaccines based on a single construct and variant might induce antibodies with limited broadly neutralizing activity.