Tissue Distribution of Human Pyruvate Kinase Isozymes

Abstract

Summary. (1) Three isozymes of pyruvate kinase found in human tissues differ in chromatographic, electrophoretic, ammonium sulfate solubility, antigenic and kinetic behavior. (2) Isozyme I is found in erythrocytes and liver, isozyme II in kidney, and isozyme III in liver, kidney, leukocytes, skeletal muscle and cardiac muscle. (3) The possible structural relationship of these isozymes to one another and their probably differing roles in regulating glucose metabolism are discussed.