The nature of the action of pancreatic extract on the inhibition of lactic acid formation in muscle

Abstract

THE fact that the formation of lactic acid in muscle is inhibited by an extract from the pancreas was first observed by Winfield and Hopkins [1915]. Foster and Woodrow [1924] pointed out that the factor responsible for the inhibition was neither trypsin, insulin, nor Cohnheim's [1904] glycolytic factor; and they also suggested that it was not the antiglyoxalase of Dakin and Dudley [1913]. Foster [1925], after further work, which was however criticised by Dudley [1926], definitely concluded that the pancreatic factor was not antiglyoxalase. Since that time research in this laboratory by other workers [Reay, 1927; Downes, 1927] has made it seem desirable to add confirmation to portions of Foster's work.