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Immunotherapy and gene therapy of cancer using antibodies or their genes against tumor-associated antigens.
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2004
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ImmunologyTumor-associated AntigensPathologyImmune Cell TherapyImmunotherapyTumoricidal EffectTumor SpecificityTumor BiologyTumor ImmunologyOncologyCancer VaccinesRadiation OncologyCancer ResearchHealth SciencesTherapeutic VaccineCancer TreatmentTumor MicroenvironmentCancer ImmunosurveillanceImmune Checkpoint InhibitorMedicineCancer TherapeuticsCurrent Significance
The purpose of this article is to review the current significance of anti-tumor-associated antigen (TAA) antibodies in the therapy of cancer. Current data suggest that antibodies or their genes against TAAs can be used in order to increase the tumor specificity of various therapeutic approaches against cancer, thereby enhancing the tumoricidal effect of each treatment while reducing the side-effects.