Studies on the Immunoglobulin Allotypes of Asiatic Populations

Abstract

The results of immunoglobulin typing of 268 Tuvinians for G1m (f, z, a, and x), G3m (b, 0, 1, 3, 5, c3, 5, g, s, t and v), A2m (1 and 2) and Km (1) indicate these southern Siberians to have the Caucasian haplotype Gmf; bAm1 (0.100), the Oriental haplotypes Gmf, a; bAm1 (0.022), Gmf, a; bAm2 (0.040), Gmz, a; b, s, tAm1 (0.027) and Gmz, a; b, s, tAm2 (0.107). The haplotypes distribution for Gmz, a; gAm1 (0.279), Gmz, a; gAm2 (0.065), Gmz, a; x, gAm1 (0.101) and Gmz, a, x; gAm2 (0.030) are similar to those found in oriental populations. The striking feature of this population is the presence of Gmz, a; bAm1 (0.108) and Gmz, a; bAm2 (0.122) previously thought to be characteristic of African or Papuan populations, indicating that a third focus of the Gmz; a; b haplotypes exists in Central Asia. The Km1 frequency observed (0.125) is intermediate between Caucasian and previously studied northern Oriental populations.