DO ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES CAUSE WEGENER’S GRANULOMATOSIS AND OTHER FORMS OF NECROTIZING VASCULITIS?

Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase in Patients with Systemic Vasculitis and Idiopathic Necrotizing and Crescentic Glomerulonephritis

Ronald J. Falk, J. Charles Jennette · New England Journal of Medicine · 1988 · 1.4K citations

Medicine, Immunology, Pathology +17

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

Ronald J. Falk, Regina S. Terrell, L Charles et al. · Proceedings of the National Academy of Sciences · 1990 · 1.3K citations

Life Sciences, Immunology, Pathology +17

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

Roel Goldschmeding, C. Ellen van der Schoot, Daan ten Bokkel Huinink et al. · Journal of Clinical Investigation · 1989 · 440 citations · Full text

Life Sciences, Immunology, Pathology +16

Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre

The Lancet · 1990 · 413 citations

Medicine, Immunology, Pathology +8

Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase [see comments]

JL Niles, R T McCluskey, MF Ahmad et al. · Blood · 1989 · 411 citations · Full text

Life Sciences, Immunology, Pathology +12