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99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis.
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1992
Year
ImmunologyPsoriatic ArthritisJoint SwellingHuman Immunoglobulin ScintigraphyInflammationRheumatoid DisorderOsteoarthritisInflammatory Rheumatic DiseaseRheumatoid ArthritisRadiologyHealth SciencesRheumatologyAutoimmune DiseaseMusculoskeletal ImagingRheumatic DiseasesAutoimmunityJoint ActivityMbq 99Mtc-iggMedicine
The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later. This resulted in excellent images of inflamed synovium. Scores for 99mTc-IgG joint scintigraphy correlated highly with scores for joint swelling and C-reactive protein levels, weakly with pain scores and not with radiographic scores of joint destruction. These results suggest that 99mTc-IgG joint scintigraphy may provide an objective test to detect synovitis and measure the activity of the disease.