Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives. - Concepedia

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Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives.

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2001

Year

Bożena Modzelewska‐Banachiewicz, E Jagiełło-Wójtowicz, Ewa Wielosz

Biological ActivityDerivativesNatural SciencesMedicineN'-substituted AmidrazonesOrganic Chemistry1,3,4-Thiadiazole DerivativesChemistryReaction ConditionsHeterocycle ChemistryPharmacologyDerivative (Chemistry)Synthetic ChemistryDrug Discovery

Abstract

Synthesis of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives via the condensation of N'-substituted amidrazones and p-phenylenediisothiocyanate (PPD) is presented. The reaction conditions are discussed. Results of a preliminary pharmacological screening are presented.