Stop-flow analyses of mepiperphenidol and mecamylamine in the dog

Abstract

The renal tubular excretion of mepiperphenidol was studied in dogs utilizing the stop-flow technique. Secretion of mepiperphenidol was shown to be localized in the proximal part of the nephron. The tubular excretion of mecamylamine was studied by this technique during acidification and alkalinization of the urine. Secretion of mecamylamine was shown to occur in the proximal area of the nephron irrespective of the urinary pH. The distal area of the tubule was shown to be the site of reabsorption of the base when the urine was alkaline. It was also shown that the secretion and the reabsorption of mecamylamine can occur simultaneously in the separate areas of the nephron.