Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 1982 · 14 citations · 5 references
MedicineNeurologyPharmacotherapyClinical NeuroscienceNeurologic PharmacotherapyNeuropharmacologyCerebellar FunctionGabaergic NeurochemistryGabaergic PharmacologyGabaergic SignalingGlutamatergic PharmacologyAtaxia SyndromesGaba AgonistsGaba AntagonistsGaba Receptor AntagonismGaba Transaminase InhibitionGabaergic DysfunctionGabaergic Neurotransmission In DiseaseGabaergic Neurotransmission Modulation
Gamma-Vinyl GABA, an irreversible inhibitor of GABA-transaminase, was administered orally in two daily doses of 250 mg to 10 patients with cerebellar ataxia (9 with Friedreich's ataxia, one with olivo-ponto-cerebellar atrophy) for at least one month in an open study. No significant difference occurred in the disability scores of cerebellar symptomatology for the group as a whole, but seven patients showed some improvement in scores with treatment and two patients claimed marked subjective amelioration. Tolerance to Gamma-Vinyl-GABA treatment was excellent. These preliminary results suggest that further studies with well-tolerated agents which enhance CNS GABA-ergic function are warranted in patients with cerebellar ataxia.
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