CD4+/CD25+ T-Lymphocytes and Th1/Th2 regulation in dilated cardiomyopathy.

Abstract

Increased peripheral CD4+/CD25+ T-cells found in chronic DCM could be a useful prognostic marker in DCM progress. Increased synthesis of IL-2 and IFN-γ and varying IL-10 levels reflects a Th1 pattern of immune response during chronic disease and implies active cellular immunity process, related to poor prognosis. Thus, analysis of the Th1/Th2 phenotype may be useful in disease monitoring in patients with DCM. This paper is a part of PhD thesis. It has been published at the abstract book of the Acute Cardiac Care congress 2010.