Concepedia

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Decreased leukocyte adhesion with anti-CD18 monoclonal antibodies is mediated by receptor internalization.

11

Citations

0

References

1992

Year

Bent Rubin, Ori D. Rotstein, Gergely L. Lukács, Debora Bailey, Alexander D. Romaschin, Ph. Walker
PubMed

Abstract

IB4 decreases PMN-endothelial cell adhesion but does not stimulate neutrophil oxidative metabolism or degranulation. These data suggest that reduced adhesion may be the result of internalization of the CD18/IB4 complex. Anti-CD18 monoclonal antibodies may be useful in preventing PMN adhesion without the potentially deleterious effects of cell activation.