Publication | Closed Access
Acceleration of spontaneous intimal--subintimal changes in rabbit aorta by a prolonged moderate carbon monoxide exposure.
60
Citations
0
References
1969
Year
Subintimal ChangesVascular DiseaseOxidative StressPublic HealthRabbit AortaMicrovascular DysfunctionCardiologyCarbon Monoxide ExposureAtherosclerosisAnimal PhysiologyPulmonary CirculationVascular AdaptationVascular BiologySpontaneous IntimalCollagen FormationCardiovascular DiseaseTissue HypoxiaPhysiologyEndothelial DysfunctionTissue OxygenationCardiovascular PhysiologyMedicineAnesthesiology
Rabbits were exposed to 90 ppM CO by volume (11% COHb) for 3 months. More exposed animals had areas in the heart with hyperemia and/or hemorrhages, a greater degree of fibrous plaque formation on the aorta, and definitely more intimal-subintimal changes, including focal subintimal edema, endothelial cellular proliferation and breakdown, splitting up of subintimal fibrils, and collagen formation. There were no macroscopic differences, except abnomal amounts of fluid in serous cavity in experimental animals indicating increased endothelial membrane permeability. Tissue hypoxia (carbon monoxide exposure) seems to play a basic role in the development of focal vascular changes of the atherosclerotic type.