Vitamin B12 binding capacity of normal and leukemic sera.

Abstract

Abstract A method for the measurement of binding capacity of serum for vitamin B 12 is described. With this method, sera from normal subjects and patients suffering from chronic granulocytic leukemia, lymphocytic leukemia (acute or chronic), and various other conditions were studied. The serum of chronic granulocytic leukemia patients showed an increase and that of lymphocytic leukemia patients a decrease of the binding capacity for vitamin B 12 .