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Morphometric Analysis of Platelets in Bernard-Soulier Syndrome: Size and Configuration in Patients and Carriers
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1984
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ThrombopoiesisThrombosisBernard-soulier PlateletsThin SectionsBlood PlateletHematologyBernard-soulier SyndromePathologyPlatelet PathobiologyMinor AxesHemostasisCoagulopathyNeurologyBleeding DisorderMedicineAtherosclerosisMorphometric Analysis
Quantitative ultrastructural morphometric analysis has been carried out on thin sections of platelets from two Bernard-Soulier sisters and their parents. Measurements were made for the major and minor axes, axial ratios, cross-sectional circumference and cross-sectional area. Platelets were collected either into CPD anticoagulant or directly into glutaraldehyde. The results confirm that Bernard-Soulier platelets are significantly larger than normals (p less than 0.05) in all the parameters mentioned and indicate (I) that the morphology of platelets from Bernard-Soulier patients is affected by the presence of anticoagulant, and (II) a more spherocytic configuration is characteristic of Bernard-Soulier disease both in patients and carriers.