Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha. - Concepedia

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Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha.

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References

1997

Year

Nada Alaaeddine, John A. DiBattista, J.-P. Pelletier, J M Cloutier, Kayghobad Kiansa, Magali Dupuis, Johanne Martel‐Pelletier

Abstract

TNF-R55 is the major receptor isoform transducing PGE2 and COX-2 responses to TNF-alpha in OA synovial fibroblasts; soluble receptors could be involved in facilitating the binding of TNF-alpha to its receptor.