Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages

Abstract

The induction of iNOS and COX-2 by LPS in equine macrophages suggests these enzymes may be important in the pathophysiology of sepsis. Pharmacologic modulation of iNOS and COX-2 activity may represent a novel therapeutic target in the management of endotoxemia in horses.