Elevation of Blood Glucose Following Anaesthetic Treatment in C57Bl/6 Mice

Abstract

In recent years, targeted disruption of numerous genes in mice has become eminently important in the study of genotype/phenotype relationships in diabetes and metabolism research [1] [2]. The inbred strain of mice most frequently used for such knock-out studies is termed C57Bl/6. Furthermore, mice carrying db/db or ob/ob mutations, which have been extensively studied by researchers for decades, are commonly bred on this particular genetic background.