PubMed · 1992 · 25 citations · 0 references
MedicinePharmacologyVeterinary PhysiologyAntimicrobial PharmacologyAntimicrobial PharmacotherapyPharmacodynamicsGastrointestinal DiseaseGastrointestinal FunctionGastrointestinal MotilityGastrointestinal PathophysiologyGastrointestinal PharmacologyGastrointestinal PhysiologyAltered Gastrointestinal MotilityDisorderGastrointestinal Motility ControlGlycosidic LinkagesMacrolide AntibioticsMacrolide TherapyMotility PharmacologyTransducers
The effect of macrolide antibiotics on gastrointestinal motility was studied in unanaesthetized dogs by using strain-gauge transducers. Midecamycin acetate, leucomycin, josamycin and acetylspiramycin, which are 16-membered macrolides, did not affect the gastrointestinal motility and no symptoms of gastrointestinal disorder were observed. On the other hand, erythromycin, roxithromycin, clarithromycin and oleandomycin, which are 14-membered macrolides, caused giant contraction and disorder symptoms. Moreover, it was found that the glycosidic linkages of the lactone ring were necessary for a structure to exert strong contractile activity.