PubMed · 1995 · 11 citations · 0 references
Life SciencesImmunologyPharmacologyGastrointestinal PharmacotherapyImmunoregulationInflammationGastrointestinal InflammationGrowth Factor SignalingGrowth Factor TherapyInflammatory Bowel DiseaseInflammatory MediatorsInflammatory SignalingAnimal Disease ModelsAnti-inflammatory TherapeuticsColonic PathologyGrowth Factor-mediated RepairInflammatory Bowel Disease ImmunopathogenesisInflammatory Bowel Disease PathophysiologyInflammatory Bowel Disease TherapyPlatelet-derived Growth Factor Inhibition
The role of Platelet-Derived Growth Factor (PDGF) was investigated in treatment of experimental inflammatory bowel disease (IBD) in animal models. A new model of IBD induced by the sulfhydryl (SH) alkylator iodoacetamide revealed that the most appropriate concentration of iodoacetamide is 6% given intracolonically once. Daily treatment with PDGF dose-dependently accelerated the healing of colonic erosions, ulcers and inflammation.