Chemical and Chemotherapeutical Studies on the Furan Derivatives. XXX

Abstract

A total of 28 kinds of Panfuran-type compounds, in which the nitrofuran and heterocyclic rings are connected through one double bond, were prepared and their antibacterial action was tested with Streptococcus haemolyticus, Staphylococcus aureus, Escherichia coli, Shigella flexineri, and Bacillus subtilis. The quinoline compounds were found to be most effect as a chemotherapeutic and acetamidoquinoline derivative showed the most marked effect, inhibiting bacterial growth of Bacillus subtilis in a very dilute solution of ca. 2, 000, 000, 000 dilution.