Journal of the American Veterinary Medical Association · 1979 · 19 citations · 0 references
MedicinePathologyVeterinary PathologyCellular PathologyImmunopathologyMonoclonal AntibodiesBone Marrow PathologyBone PathologyBone TumorsImmunoglobulin DisordersMultiple MyelomaVeterinary ImmunologyCanine Tumor PathologyImmunoglobulin Class ProfilesMultiple Myeloma Of BoneMyeloma PathogenesisNeurologic DeficitsOsteolytic Bone DiseaseOsteolytic Bone LesionsOsteolytic Lesion Formation
A diagnosis of vertebral multiple myeloma, based on radiographic evidence of osteolytic lesions and the finding of monoclonal paraprotein and large numbers of plasma cells in bone marrow biopsies, was made in a mature Doberman Pinscher. The abnormal serum paraprotein was a cryoglobulin of the immunoglobulin A class. Neurologic signs associated with the tumor included pain, progressive pelvic limb paresis, and paraplegia that developed during a 6-week period.