Hospital Practice · 1972 · 83 citations · 8 references
MedicinePharmacologyPharmacotherapyBiochemical PharmacologyClinical PharmacologyPharmacodynamicsContraceptive PharmacotherapyReproductive PharmacologyProstaglandin ActivityProstaglandin Biosynthesis InhibitorsProstaglandin PharmacologyProstaglandin PhysiologyProstaglandin ProductionProstaglandin RegulationProstaglandin SignalingProstaglandin Synthesis Inhibition
Demonstration that the aspirin-like compounds block prostaglandin synthesis has not only provided the long-sought explanation of how these drugs work but is throwing considerable light on the physiologic functions of the prostaglandins. It has also suggested possible new uses for the drugs (perhaps, for example, to prevent unwanted abortions) and new contraindications (e.g., where wound healing might be delayed).
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