PubMed · 2015 · 830 citations · 26 references
DentistryOral BiologyOral PathologyCarcinogenesisOral Cancer BiologyOral OncologyOral Cancer PrognosisOral CarcinogenesisOral Cavity CancerOral NeoplasiaOral Potentially Malignant DisordersSquamous Cell CarcinomaMalignant Oral LesionsOral Cancer IncidenceOral Cavity LesionsOral Cavity PathologyOral Epithelial CarcinogenesisPotentially Malignant Oral DisordersPotentially Malignant Oral Mucosal DisordersSquamous Cell Carcinoma Pathology
Oral cancer is one of the 10 most common cancers in the world, with a delayed clinical detection, poor prognosis, without specific biomarkers for the disease and expensive therapeutic alternatives. This review aims to present the fundamental aspects of this cancer, focused on squamous cell carcinoma of the oral cavity (OSCC), moving from its definition and epidemiological aspects, addressing the oral carcinogenesis, oral potentially malignant disorders, epithelial precursor lesions and experimental methods for its study, therapies and future challenges. Oral cancer is a preventable disease, risk factors and natural history is already being known, where biomedical sciences and dentistry in particular are likely to improve their poor clinical indicators.
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Comprehensive genomic characterization of head and neck squamous cell carcinomas
2011: the immune hallmarks of cancer
Federica Cavallo, Carla De Giovanni, Patrizia Nanni et al. · Cancer Immunology Immunotherapy · 2011 · 416 citations · Full text
Medicine, Immunology, Oncology +17