Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that <i>XRCC2</i> is a Fanconi anaemia gene

Abstract

XRCC2/FANCU is a FA gene, as is another RAD51 paralog gene, RAD51C/FANCO. Notably, similar to a subset of FA genes that act downstream of FANCD2, biallelic mutation of XRCC2/FANCU has not been associated with bone marrow failure. Taken together, our results yield important insights into phenotypes related to FA and its genetic origins.