PubMed · 1986 · 16 citations · 0 references
Life SciencesDermatologyImmunologyAutoimmunityImmunopathologyRheumatologyAutoantigensAutoimmune DiseasesAutoimmune Rheumatic DiseasesAutoimmune ToxicityInflammatory ArthritisRheumatoid ArthritisAutoimmune Adverse Drug ReactionsHla Class Ii MoleculesHla-associated Adverse Drug ReactionsImmune-related Skin ToxicityRheumatoid Arthritis PharmacotherapyRheumatologic ToxicitiesTiopronin Therapy
Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 frequency was observed in patients with RA except for the Tiopronin related nephritis group.