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Effect of antibiotics on the in vitro neutrophil chemotactic response.
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1976
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ImmunologyAntimicrobial ChemotherapyAntibiotic ResistanceDrug ResistanceInflammationAntimicrobial TherapyInfection ControlNeutrophil Chemotactic ResponseChemotactic ResponseAntimicrobial ResistanceHealth SciencesAllergyFollowing AntibioticsGranulocyteAntimicrobial PharmacokineticsPharmacologyClinical MicrobiologyPhagocyteAntimicrobial SusceptibilityAntibioticsAntimicrobial PharmacodynamicsMedicine
Polymorphonuclear neutrophilic leukocyte chemotaxis was examined in vitro in the presence of the following antibiotics: tetracycline, chloramphenicol, erythromycin, gentamicin, methicillin, sulfadiazine, cephalothin, oxacillin, nafcillin and clindamycin. Results indicate that high concentrations (1 mg/ml) of tetracycline, nafcillin, erythromycin and sulfadiazine inhibited the chemotactic response of neutrophils. Tetracycline produced an inhibition at concentrations as low as 1mug/ml. A stimulation of the neutrophil chemotactic response was observed in the presence of chloramphenicol in all concentrations. The results are discussed with particular emphasis on the implications to host immunity.