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Influence of vitamin C on the metabolism of arachidonic acid and the development of aortic lesions during experimental atherosclerosis in rabbits.
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1984
Year
NutritionVascular DiseaseOxidative StressMetabolic SyndromeProstacyclin ProductionExperimental AtherosclerosisPublic HealthAtherosclerosisDyslipidemiaAnimal PhysiologyAnimal NutritionArachidonic AcidCholesterol-rich DietVitamin CVascular BiologyPharmacologyCardiovascular DiseasePhysiologyEndothelial DysfunctionLipoprotein MetabolismArterial DiseaseMetabolismMedicine
Feeding rabbits a cholesterol-rich diet (0.3%) resulted in morphological changes and a decrease in the prostacyclin production by the aortic endothelium. Addition of vitamin C (0.1%) to the cholesterol-rich diet resulted in a decreased lipid infiltration and intimal thickening. Although there was a tendency to restore the prostacyclin output, vitamin C, in the amount administered, was unable to completely normalise the endothelial PGI2 production.