An explanation of the asymmetric binding of sugars to the human erythrocyte sugar-transport systems

Abstract

6-O-Alkyl-d-galactoses competitively inhibit the erythrocyte sugar-transport system when added to the outside of the cells, but not to the inside. n-Propyl beta-d-glucopyranoside competitively inhibits the system on the inside of the cells, but not on the outside. A model for sugar transport is proposed.