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Uterus estrogen receptors' binding capacity is reduced in rat if exposed by benzpyrene neonatally.
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1993
Year
Estrogen Receptor DensityReproductive HealthFemale Reproductive FunctionReproductive EndocrinologyMolecular PharmacologyReceptor MaturationPublic HealthHormonal ReceptorEndocrinologyPharmacologyOvarian HormoneUterus Estrogen ReceptorEndocrine DisruptorsBinding CapacityUterine ReceptivityPhysiologyUterus Estrogen ReceptorsMedicineReproductive Hormone
During the critical period of receptor maturation within the first 5 days after birth female rats were treated with benzpyrene three times and their uterus estrogen receptor characteristic were examined in adulthood. Estrogen receptor density decreased significantly. There was no alteration in receptor affinity. Present experiment draws attention to the disadvantageous effect of aromatic hydrocarbons coming from the polluted air on steroid receptor development.