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Flavonoids and a Sesquiterpene Lactone from<i>Tanacetum microphyllum</i>Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages
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2004
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Nitric OxideImmune RegulationImmunologyOxidative StressInflammationMedicinal ChemistryPhytochemicalAllergyBiochemistryInflammatory ProcessChronic InflammationSesquiterpene LactonePharmacologyInflammatory DiseasePhagocyteAnti-inflammatoryNatural SciencesAnti-inflammatory CompoundsHerb-drug InteractionMedicine
In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) in a concentration-dependent manner. In the tumour necrosis factor-alpha (TNF-alpha) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-alpha. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.