Influence of Meal Frequency on Postprandial Variations in the Production and Absorption of Volatile Fatty Acids in the Digestive Tract of Conscious Pigs

Abstract

Five Large White pigs of 62.2 +/- 1.4 kg mean body weight were fitted with permanent catheters in the portal vein and carotid artery and with an electromagnetic flow probe around the portal vein to study the absorption of volatile fatty acids (VFA) by measuring the concentration of these metabolites in hourly blood samples, and by determining the portal blood flow rate for a period of 12 h after intake of a single 800-g meal (6% crude fiber) preceded by 12 or 24 h of fasting. The portal concentration of VFA mixture always highly exceeded the arterial concentration. The arterial concentrations of propionic, butyric, valeric and isovaleric acids were nearly null, accounting for an almost complete uptake of these VFA by the liver. Acetic acid also was taken up, but to a lesser extent. Total VFA absorption during 12 h was 64% higher (P less than .05) after 12 h (1,160 +/- 100 mmol/12 h) than after 24 h of preprandial fasting (740 +/- 83 mmol/12 h). It increased after the meal (P less than .05) from 82.3 +/- 7.8 mmol/h between the first and fourth hour to 107.8 +/- 7.5 mmol/h between the fifth and tenth hour when the preprandial fasting lasted 12 h; a nonsignificant increase also was found when fasting prior to the meal lasted 24 h. The composition of the VFA mixture was not modified by the length of preprandial fasting. With this type of diet there was a large predominance of acetic acid (52%) followed by propionic and butyric acids (36 and 8.5%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)