FORMULATION AND EVALUATION OF FAMOTIDINE FLOATING MICROSPONGES

Abstract

Floating drug delivery system (FDDS) are of particular interest for drugs that are locally active and have narrow absorption window in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH values. The Micro sponge Delivery System (MDS) is a patented polymeric system consisting of porous microspheres. These are tiny sponge like spherical particles that consist of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface through which active ingredient are released in a controlled manner. Famotidine floating microsponges are prepared to improve site specific absorption of drug for peptic ulcer treatment. Modified quasi emulsion solvent diffusion method was used to formulate microsponges. Different concentrations of EudragitS100 and Polyvinyl alcohol were used and the prepared microsponges were evaluated for % entrapment efficiency, % buoyancy and % cumulative drug release. It was found that the % entrapment efficiency was 88.3%, % buoyancy was 76.4% and % cumulative drug release was 86.9% for F6 formulation. This study presents a new approach based on floating ability of microsponges for treatment of ulcer.