Intracavernous Pressure as an Experimental Index in a Rat Model for the Evaluation of Penile Erection

Abstract

No AccessJournal of Urology1 Apr 1992Intracavernous Pressure as an Experimental Index in a Rat Model for the Evaluation of Penile Erection Kuang-Kuo Chen, Julie Y.H. Chan, Luke S. Chang, Ming-Tsun Chen, and Samuel H.H. Chan Kuang-Kuo ChenKuang-Kuo Chen , Julie Y.H. ChanJulie Y.H. Chan , Luke S. ChangLuke S. Chang , Ming-Tsun ChenMing-Tsun Chen , and Samuel H.H. ChanSamuel H.H. Chan View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37500-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail This report communicates our attempt to design a small animal model for the evaluation of penile erection, based on the pharmacological responses of cavernous tissues in the rat that resemble those of human subjects. Male adult Sprague-Dawley rats anesthetized with pentobarbital sodium were used in conjunction with papaverine and prostaglandin E1, two vasoactive drugs most commonly used in clinical management of impotence. Intracavernous administration of papaverine (0.05, 0.1, 0.02, 0.4 or 0.8mg.) induced a progressive increase in intracavernous pressure that peaked at 0.4mg. This effect was associated with visible penile erection that became conspicuous when accompanied by additional bursts of transient intracavernous pressure fluctuations. The duration of papaverine-induced increase in intracavernous pressure was significantly shortened by clonidine (15μg., intracavernous). Injection of prostaglandin E1 (1, 2 or 4μg.) into the corpus cavernosum also elicited an elevation in intracavernous pressure, but the responses exhibited acute tachyphylaxis. By manifesting a response to papaverine and prostaglandin El that is similar to that in human, we conclude that the intracavernous pressure in the rat may represent a suitable index for the evaluation of penile erection in small laboratory animals. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByKimura Y, Naitou Y, Wanibuchi F and Yamaguchi T (2018) Characterization of Intracavernous Pressure Increase Induced by Ym348, a Novel 5-HT2C Receptor Agonist, in Anesthetized RatsJournal of Urology, VOL. 175, NO. 5, (1953-1957), Online publication date: 1-May-2006.Steers W (2018) Editorial: Tachyphylaxis and Phosphodiesterase Type 5 InhibitorsJournal of Urology, VOL. 168, NO. 1, (207-207), Online publication date: 1-Jul-2002.GEMALMAZ H, WALDECK K, CHAPMAN T, TUTTLE J, STEERS W and ANDERSSON K (2018) IN VIVO AND IN VITRO INVESTIGATION OF THE EFFECTS OF SILDENAFIL ON RAT CAVERNOUS SMOOTH MUSCLEJournal of Urology, VOL. 165, NO. 3, (1010-1014), Online publication date: 1-Mar-2001.ZAHRAN A, VACHON P, COURTOIS F and CARRIER S (2018) INCREASES IN INTRACAVERNOUS PENILE PRESSURE FOLLOWING INJECTIONS OF EXCITATORY AMINO ACID RECEPTOR AGONISTS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF ANESTHETIZED RATSJournal of Urology, VOL. 164, NO. 5, (1793-1797), Online publication date: 1-Nov-2000.CHEN K, CHAN J and CHANG L (2018) DOPAMINERGIC NEUROTRANSMISSION AT THE PARAVENTRICULAR NUCLEUS OF HYPOTHALAMUS IN CENTRAL REGULATION OF PENILE ERECTION IN THE RATJournal of Urology, VOL. 162, NO. 1, (237-242), Online publication date: 1-Jul-1999.ESCRIG A, MARIN R and MAS M (2018) REPEATED PGE1 TREATMENT ENHANCES NITRIC OXIDE AND ERECTION RESPONSES TO NERVE STIMULATION IN THE RAT PENIS BY UPREGULATING CONSTITUTIVE NOS ISOFORMSJournal of Urology, VOL. 162, NO. 6, (2205-2210), Online publication date: 1-Dec-1999.Chen K, Chan S, Chang L and Chan J (2018) Participation of Paraventricular Nucleus of Hypothalamus in Central Regulation of Penile Erection in the RatJournal of Urology, VOL. 158, NO. 1, (238-244), Online publication date: 1-Jul-1997. Volume 147Issue 4April 1992Page: 1124-1128 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsprostaglandinpenile erectionpapaverineclonidineratsMetricsAuthor Information Kuang-Kuo Chen More articles by this author Julie Y.H. Chan More articles by this author Luke S. Chang More articles by this author Ming-Tsun Chen More articles by this author Samuel H.H. Chan More articles by this author Expand All Advertisement Loading ...