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Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors.
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2004
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Psychotropic MedicationPsychopharmacologyPharmacotherapyForced Swimming TestSocial SciencesMolecular PharmacologyStrongest ShorteningPsychoactive DrugPsychiatryCb1 ReceptorsBehavioral PharmacologyDepressionNeuropharmacologyPharmacologyNeurophysiologyFunctional SelectivityPhysiologySelective AgonistNeuroscienceMedicineAlpha-adrenergic Pharmacology
The antidepressant effect of ACEA (arachidonyl-2-chloroethylamide), a selective agonist of CB1 receptors, and its interaction with fluoxetine were studied in mice. ACEA (1.0 and 2.0 mg/kg i.p.) reduced the immobility time in the forced swimming test and attenuated the head - twitch response to L-5-HTP. The concomitant administration of ACEA (1.0 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.) resulted in the strongest shortening of immobility time, significant in comparison with both ACEA and fluoxetine given alone. The obtained results indicate that ACEA may have antidepressant efficacy and shows a synergistic effect when given with fluoxetine in the forced swimming test.